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Some people gain weight when taking a certain antidepressant, while others dont. Generally speaking, dissertation literature review some antidepressants seem more likely to cause weight gain than others. These include: Certain tricyclic antidepressants, such as amitriptyline, imipramine (Tofranil) and doxepin. Structure-activity relationships (SAR) are the traditional practices of medicinal chemistry which try to modify the effect or the potency (i.e. activity) of bioactive chemical compounds by modifying their chemical structure. Tramadol is a prescription drug used to treat pain. Learn about side effects, drug interactions, dosages, warnings, and more. Albendazole is an anthelmintic (an-thel-MIN-tik) or anti- worm medication. It prevents newly hatched insect larvae (worms) from growing or multiplying in your body. But even if you do start gaining weight, you should always talk to your doctor before you make any changes to your routine. Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit.